Peer-reviewed veterinary case report
Oral mitemcinal speeds up stomach emptying in dogs with slow digestion
By Onoma, Mitsu et al.Ā·Published in Clinical and experimental pharmacology & physiologyĀ·2008Ā·Fuji-Gotemba Research Laboratories, JapanĀ·View original on PubMed ā
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Original publication title: Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normal and experimentally delayed gastric emptying in conscious dogs.
- Species:
- dog
Plain-English summary
A group of dogs with delayed gastric emptying were given a new medication called mitemcinal to see if it could help them digest food more quickly. The dogs showed significant improvement in how fast their stomachs emptied after taking mitemcinal, especially at higher doses. In comparison, another medication called cisapride did not have the same positive effect. Mitemcinal also helped stimulate normal digestive movements in the stomach and intestines. Overall, mitemcinal appears to be a promising treatment for dogs suffering from slow digestion.
People also search for: dog delayed gastric emptying treatment Ā· mitemcinal for dogs Ā· cisapride side effects in dogs
Abstract
1. We examined effects of orally administered mitemcinal, an erythromycin-derived motilin agonist, on gastric emptying and antroduodenal motility in conscious normal dogs and conscious dogs with experimentally delayed gastric emptying. For comparison, we also examined the effects of orally administered cisapride. 2. Gastric emptying was assessed by adding paracetamol to the test meal and determining three of its pharmacokinetic parameters as indices of gastric emptying. Antroduodenal motility was assessed from the output of force transducers chronically implanted in the gastric antrum and duodenum. 3. In normal dogs, mitemcinal (0.25, 0.5 and 1 mg/kg) dose-dependently accelerated gastric emptying, significantly increasing all three indices at doses of 0.5 and 1 mg/kg; cisapride (1, 3 and 10 mg/kg) had no significant effect. Mitemcinal also dose-dependently stimulated antroduodenal motility in the interdigestive and digestive states. Cisapride, at 100-fold the dose, produced similar effects in the interdigestive state, but mixed results in the digestive state. 4. In dogs with delayed gastric emptying induced by subcutaneous clonidine (0.03 mg/kg), mitemcinal (0.25, 0.5 and 1 mg/kg) dose-dependently improved delayed gastric emptying, significantly increasing two of three indices at a dose of 1 mg/kg. Cisapride (1, 3 and 10 mg/kg) caused non-significant increases in the indices of gastric emptying, with roughly bell-shaped dose-response curves. The highest dose of mitemcinal (1 mg/kg) also stimulated antroduodenal motility. 5. In dogs with delayed gastric emptying induced by vagotomy, mitemcinal (0.125, 0.25 and 0.5 mg/kg) dose-dependently improved delayed gastric emptying, significantly increasing all three indices at doses of 0.25 and 0.5 mg/kg. Cisapride (3 mg/kg) restored the indices to roughly prevagotomy levels, but none of the increases was significant. Mitemcinal, at a dose of 0.25 mg/kg, also stimulated antroduodenal motility. 6. Because delayed gastric emptying is the basic characteristic of gastroparesis, the fact that mitemcinal accelerated gastric emptying in dogs with normal and delayed gastric emptying much more robustly than cisapride adds to the evidence that mitemcinal is likely to be useful for the treatment of patients with gastroparesis.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18047625/