Oral Route Infection byFrom the Beginning to the Present Day.

Abstract

is the causative agent of Chagas disease, which affects 6-7 million people worldwide. Although the possibility of oral transmission was first scientifically suggested in 1913, it was not until 1968 that the first confirmed cases of human infection via food consumption were reported. This long gap contributed to the widespread perception that oral transmission was a rare or incidental event. Over the past two decades, significant advances have been made in understanding the biological and clinical aspects of oral transmission, including the molecular mechanisms by which metacyclic trypomastigotes establish infection via the digestive route. Experimental studies in murine models have further deepened our knowledge of the biology and pathogenesis of oral infection. Concurrently, multiple outbreaks ofinfection through contaminated food and beverages have been reported across Latin America, providing valuable insights into the molecular epidemiology and clinical characteristics of this transmission route. Moreover, experimental evidence has shown that the consumption of meat from animals infected during the acute phase can also lead toinfection, highlighting carnivory as a potential alternative transmission mechanism. This review aims to comprehensively analyze oral infection by, considering clinical and epidemiological data, parasite biology, and findings from murine experimental models. Strategies for controlling foodborne transmission of Chagas disease are also discussed.