Peer-reviewed veterinary case report
Oral T-cell-rich large B-cell lymphoma in a horse.
- Journal:
- Veterinary research communications
- Year:
- 2024
- Authors:
- Peretti, Jéssica Cristina et al.
- Affiliation:
- School of Agricultural Sciences · Brazil
- Species:
- horse
Plain-English summary
A 25-year-old Crioula mare was diagnosed with a type of cancer called T-cell-rich oral large B-cell lymphoma, which is a serious tumor that affects the immune system. The mare had noticeable swelling on the right side of her face, trouble breathing, stopped eating, and was losing weight. A thorough examination showed that the tumor was growing aggressively in her sinuses and affecting nearby bones and muscles in her mouth. Unfortunately, the findings from the autopsy confirmed the presence of a large, invasive mass. The treatment outcome for this mare was not mentioned, but the nature of the disease suggests it was quite severe.
Abstract
Lymphoma is the most common tumor of hematopoietic origin in horses. The course of the disease and clinical signs vary greatly, depending on tumor location and extent. The aim of this report is to describe the occurrence of T-cell-rich oral large B-cell lymphoma with marked local infiltration in a 25-year-old Crioula mare. The mare showed an increase in volume on the right side of its face, dyspnea, anorexia, and progressive weight loss. The clinical assessment showed that the lesion was located in the rostral and caudal sinuses and was markedly invasive to adjacent structures. The autopsy revealed a yellow mass with a soft to firm consistency, infiltrating multiple bones in the skull, and extensively invading the hard palate and masseter muscle. Histologically the mass comprised an undifferentiated malignant neoplasm characterized by a densely cellular neoplasm composed of large CD20 + neoplastic B-lymphocytes admixed with sheets of small, CD3 + reactive T-lymphocytes supported by delicate fibrovascular stroma leading to the diagnosis of oral T-cell-rich large B-cell lymphoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39190130/