Peer-reviewed veterinary case report
Dog with eye tumor spreading outside the skull causing bulging eye
By Pérez, V et al.·Published in Journal of comparative pathology·2005·Departamento de Patologí, Spain·View original on PubMed →
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Original publication title: Orbital meningioma with a granular cell component in a dog, with extracranial metastasis.
- Species:
- dog
Plain-English summary
A 5-year-old male Golden Retriever was brought in because his left eye was bulging out (exophthalmos). After tests, the vet found a tumor in the eye socket that was affecting the optic nerve and had spread to the lungs and heart. The tumor was made up of unusual cells that had specific characteristics when examined under a microscope. Unfortunately, due to the aggressive nature of the tumor and its metastasis, treatment options may be limited, and the prognosis could be serious.
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Abstract
A meningioma with a significant component of granular cells is described in the left ocular orbit of a 5-year-old male Golden retriever dog that presented with exophthalmos. The neoplastic mass surrounded the optic nerve. Microscopically, the tumour was characterized by nests of large, round to polygonal cells, variable in size, with eccentric nuclei and abundant eosinophilic cytoplasm, containing PAS-positive granules. In focal areas, cells were smaller and occasionally formed whorl-like structures. Immunohistochemical analysis revealed that neoplastic cells reacted positively for vimentin and, with less intensity, for neuron specific enolase and S-100, whereas they were negative for glial fibrillary acidic protein and cytokeratins. Metastatic growths, formed by similar cells, were seen in the lung and heart.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16045918/