Peer-reviewed veterinary case report
Orexins cause epileptic activity.
- Journal:
- Peptides
- Year:
- 2012
- Authors:
- Erken, Haydar Ali et al.
- Affiliation:
- Balikesir State Hospital
- Species:
- rodent
Abstract
Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22771311/