Peer-reviewed veterinary case report
Kidney tumor with giant cells in an 8-year-old Anatolian Shepherd dog
By Haziroglu, R et al.·Published in Acta veterinaria Hungarica·2005·Department of Pathology·View original on PubMed →
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Original publication title: Osteoclast-like giant cell tumour arising from the kidney in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old female Anatolian Shepherd was diagnosed with a large tumor on her left kidney, which weighed about 8 pounds and measured over a foot in size. Unfortunately, the tumor had spread to her diaphragm and lungs, indicating it was malignant. The tumor contained unusual giant cells and showed signs of aggressive growth. This case is notable as it is the first reported instance of such a tumor originating from a kidney in dogs. Treatment options would typically include surgery and possibly chemotherapy, but the prognosis can vary significantly based on the extent of the disease.
People also search for: dog kidney tumor symptoms · Anatolian Shepherd cancer treatment · dog lung metastasis signs
Abstract
In this study, a case of osteoclast-like giant cell tumour arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26 x 22 x 12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell tumour arising from a visceral organ in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15959980/