Peer-reviewed veterinary case report
Prednisone and vinblastine chemo helps dogs with high-risk mast cell
By Thamm, D H et al.·Published in The Journal of veterinary medical science·2006·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Outcome and prognostic factors following adjuvant prednisone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases.
- Species:
- dog
Plain-English summary
A group of 61 dogs with high-risk mast cell tumors (a type of skin cancer) received a combination of prednisone and vinblastine chemotherapy after their tumors were surgically removed. Most dogs tolerated the treatment well, with only mild side effects noted in about a quarter of them. The dogs had a median disease-free interval of over three years, and 65% were still alive after three years. Dogs with grade II tumors had an excellent survival rate, while those with grade III tumors had a median survival of about 1,374 days. Overall, this treatment showed promising results for dogs at high risk for metastasis.
People also search for: dog mast cell tumor treatment · prednisone vinblastine for dogs · dog skin cancer survival rate
Abstract
The medical records of 61 dogs with MCT at high risk for metastasis that were treated with prednisone and VBL following excision+/-radiation therapy were reviewed, and median disease-free interval (DFI), median overall survival time (OS) and prognostic factors assessed. Adverse effects, mostly mild, were noted in 26% of patients, usually after the first VBL dose. 6.5% experienced severe neutropenia. The DFI was 1305 days, and the OS was not reached, with 65% alive at 3 years. 100% of dogs with "high-risk" grade II MCT were alive at 3 years. The OS for dogs with grade III MCT was 1374 days. Histologic grade, location (mucous membrane vs. skin) and use of prophylactic nodal irradiation predicted outcome. Prednisone and VBL chemotherapy is well tolerated, and results in good outcomes following surgery in dogs with MCT at high risk for metastasis. High-grade and mucocutaneous tumors had a worse outcome, and the use of prophylactic nodal irradiation appeared to improve outcome in this group of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16820715/