Peer-reviewed veterinary case report
Electrochemotherapy outcomes for plasma cell tumors in dogs
By Santos Dos Anjos, Denner et al.·Published in Topics in companion animal medicine·2020·Departament of Veterinary Clinic and Surgery, Brazil·View original on PubMed →
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Original publication title: Outcome Following Curative-Intent Electrochemotherapy for Extramedullary Plasmocytoma in Dogs - Case Reports.
- Species:
- dog
Plain-English summary
Four dogs with plasma cell tumors, known as extramedullary plasmocytomas (EMP), were treated with electrochemotherapy after their owners declined surgery. The tumors were located in different areas, including the mouth, toes, and lip. During the treatment, the dogs received a chemotherapy drug either through an IV or directly into the tumor. After the procedure, they experienced temporary swelling and ulceration, but these side effects healed completely within a month. Remarkably, all four dogs achieved complete remission, with the duration of remission lasting from 90 to 695 days, indicating that electrochemotherapy can be an effective option for managing these tumors in dogs.
People also search for: dog plasma cell tumor treatment · electrochemotherapy for dogs · dog mouth tumor recovery · dog lip tumor treatment
Abstract
Plasma cell tumors can occur as solitary collections referred as extramedullary plasmocytoma (EMP). The present report describes four cases of EMP treated with a local nonthermal ablative approach. Four dogs were diagnosed with extramedullary plasmocytomas (EMP) in different body regions (oral cavity, digits, and lip). Since surgical excision was declined by the owners (maxillectomy; amputation or lip reconstruction), a curative-intent approach was indicated as solely treatment- electrochemotherapy (ECT). All the patients received ECT under general anesthesia using bleomycin intravenously (15,000 UI/m²) or cisplatin intratumorally (1mg/cm³). All dogs developed transitory ulceration and swelling one-week after procedure that completely healed within 30 days post-ECT. Complete remission was achieved in all cases and lasted for 515 (oral case), 695 (one digit), 90 (another digit case) and 240 (lip) days. These results suggested that ECT promoted remission in EMP cases being a possibility for local control in dogs affected by this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32690286/