Peer-reviewed veterinary case report
Survival times in dogs with invasive adrenal tumors without surgery
By G. Fontes et al.·Published in Journal of the American Veterinary Medical Association·2024·View original on Semantic Scholar →
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Original publication title: Outcome in dogs with invasive adrenal gland tumors that did not pursue adrenalectomy.
- Species:
- dog
Plain-English summary
A group of 32 dogs with invasive adrenal tumors, which had spread into nearby blood vessels, did not undergo surgery due to high risks like sudden death or severe bleeding. Most of these dogs had a very short survival time, with a median of just 50 days after diagnosis. Only two dogs survived longer than this period, with one receiving radiation therapy and another being treated with a medication called toceranib phosphate. Unfortunately, the majority of the dogs either died or were euthanized, often due to complications like internal bleeding.
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Abstract
OBJECTIVE To report the survival times in dogs diagnosed with adrenal tumors with vascular or soft tissue invasion that did not undergo adrenalectomy. ANIMALS Retrospective case series of 32 client-owned dogs. METHODS The medical records of a referral veterinary hospital were reviewed to identify dogs that were diagnosed with an invasive adrenal mass and did not undergo adrenalectomy between January 2013 and December 2022. Data collected included signalment, examination findings, and diagnostic results from the initial presentation. Descriptive statistics were calculated to summarize dog signalment information, and Kaplan-Meier survival analysis was performed for calculation of median survival time. RESULTS Most dogs (n = 28) had vascular invasion, primarily into the caudal vena cava. Surgery was offered but not pursued due to perceived risk of sudden death (n = 5), risk of hemorrhage (4), or concurrent diagnosis of disseminated intravascular coagulation (1). Only 1 dog pursued stereotactic body radiation therapy, and 1 was prescribed toceranib phosphate (Palladia). Of these 32 dogs, 30 (93.8%) died or were euthanized and 2 (6.2%) dogs survived. The median follow-up time was 49 days (range, 0 to 1,910 days). The median survival time was 50 days (95% CI, 4 to 194 days). The most common cause of death or euthanasia was hemoabdomen (n = 8). CLINICAL RELEVANCE Nonsurgical management of invasive adrenal tumors was associated with short survival times in this case series.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/38599229