Peer-reviewed veterinary case report
Outcomes of plasma exchange for NSAID overdose in dogs
By Butty, Emmanuelle M et al.Ā·Published in Journal of veterinary internal medicineĀ·2022Ā·Department of Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs.
- Species:
- dog
Plain-English summary
A group of 62 dogs was treated for nonsteroidal anti-inflammatory drug (NSAID) overdose, which can happen if they accidentally ingest medications like ibuprofen or naproxen. Most of these dogs showed signs of toxicity affecting their stomach, kidneys, or nervous system. They underwent a treatment called therapeutic plasma exchange (TPE), which helped remove the drugs from their system. Remarkably, 98.4% of the dogs survived and were discharged from the hospital, with many showing no lasting kidney issues at follow-up visits. This treatment proved effective even for dogs that had ingested high doses of NSAIDs.
People also search for: dog NSAID overdose treatment Ā· therapeutic plasma exchange for dogs Ā· signs of dog ibuprofen toxicity
Abstract
BACKGROUND: Therapeutic plasma exchange (TPE) is gaining popularity for the management of nonsteroidal anti-inflammatory drug (NSAID) overdose in dogs. HYPOTHESIS/OBJECTIVES: Describe a population of dogs treated with TPE for NSAID overdose. ANIMALS: Sixty-two dogs with NSAID overdose treated with TPE. METHODS: Multicenter retrospective study of dogs treated with TPE for ibuprofen, carprofen, or naproxen overdose. RESULTS: The median dose of ibuprofen, carprofen or naproxen ingested was 533 mg/kg (range, 36-4857 mg/kg), 217 mg/kg (range, 88-625 mg/kg) and 138 mg/kg (range, 26-3000 mg/kg), respectively. Based on previously established toxic ranges for each NSAID, 2 (3.2%), 14 (22.6%), and 46 (74.2%) dogs ingested a gastrointestinal, renal, and neurological toxic dose, respectively. The median time between ingestion and presentation was 4 hours (range, 1-20 hours). The median number of plasma volumes processed was 1.6 (range, 0.4-2.2). The median TPE session duration was 2 hours (range, 1-4.5 hours). Circuit clotting developed during 8 (12.9%) sessions. Patient adverse events reported during 21 (33.8%) sessions consisted of urticaria (12.9%), asymptomatic hypocalcemia (9.6%), and hypotension (9.6%). The median duration of hospitalization was 2.25 days (range, 1-11 days). Sixty-one (98.4%) dogs survived to discharge, and none were rehospitalized. Thirty-one (91.1%) of the 34 dogs with at least 1 follow-up visit were not azotemic at the time of reevaluation. CONCLUSIONS AND CLINICAL IMPORTANCE: This population of dogs managed with TPE had excellent outcomes, even in cases of high NSAID dose ingestion. When TPE is available and the time frame is appropriate, this extracorporeal modality should be considered for the management of NSAID overdose.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35930372/