Peer-reviewed veterinary case report
Outer membrane protein C (OmpC) of Escherichia coli induces neurodegeneration in mice by acting as an amyloid.
- Journal:
- Biotechnology letters
- Year:
- 2016
- Authors:
- Sahaya Rajan, J Joseph et al.
- Affiliation:
- Central Institute of Brackishwater Aquaculture · India
- Species:
- rodent
Abstract
OBJECTIVES: Involvement of the outer membrane protein C (OmpC) of Escherichia coli in neurodegeneration was investigated using a mouse model. RESULTS: OmpC formed protease-resistant fibres that exhibited the diagnostic features of an amyloid. The spectral shift in the Congo Red and the thioflavin T assays produced features similar to neurotoxic peptides. Intramuscular administration of OmpC in mice resulted in spongiform neurodegeneration of the brain through calcium-dependent apoptosis and also showed upregulation of apoptosis related genes. Immunolocalization of OmpC in brain demonstrated the direct involvement of the porin in neurodegeneration and formation of spongiform encephalopathy. CONCLUSION: We have demonstrated the ability of OmpC of E. coli to induce neurodegeneration in mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26712371/