Peer-reviewed veterinary case report
Oxidant balance and blood mineral changes in dogs with heartworm
By Dimri, Umesh et al.·Published in Research in veterinary science·2012·Indian Veterinary Research Institute, India·View original on PubMed →
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Original publication title: Oxidant/antioxidant balance, minerals status and apoptosis in peripheral blood of dogs naturally infected with Dirofilaria immitis.
- Species:
- dog
Plain-English summary
A group of dogs infected with heartworm (Dirofilaria immitis) showed signs of health issues related to their blood. These dogs had higher levels of harmful substances and lower levels of important antioxidants and minerals like zinc, copper, and iron compared to healthy dogs. The study found that the dogs with heartworm also had more dying white blood cells, which could be linked to the disease's effects on their overall health. Understanding these changes can help veterinarians better manage heartworm disease in dogs.
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Abstract
The present study was aimed to examine lipid peroxides, antioxidants, zinc, copper, iron panels and apoptosis in peripheral blood of dogs with clinical dirofilariosis. In comparison to healthy control, erythrocytic lipid peroxides level and superoxide dismutase activity were significantly (P<0.01) higher in diseased dogs. However, level of reduced glutathione and activities of glutathione peroxidase, glutathione-S-transferase and catalase were significantly (P<0.01) lower in diseased dogs. Blood zinc, copper and iron levels in dogs with dirofilariosis were significantly (P<0.01) lower than the healthy control. The percent apoptotic peripheral leukocytes were significantly higher in dogs with dirofilariosis in comparison with healthy control. From the present study, it is concluded that significant alterations in oxidant/antioxidant balance, mineral status and rate of apoptosis in peripheral blood may be implicated in the pathogenesis of clinical canine dirofilariosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21645912/