Peer-reviewed veterinary case report
Oxidative stress as a regulator of murine atherosclerosis.
- Journal:
- Current drug targets
- Year:
- 2007
- Authors:
- Hsiai, Tzung & Berliner, Judith A
- Affiliation:
- University of Southern California · United States
Abstract
Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2-) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3-6].
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18220699/