Peer-reviewed veterinary case report
Oxidative stress during dog surgery is lower with propofol than
By Lee, Jae Yeon·Published in The Journal of veterinary medical science·2012·Department of Veterinary Surgery, South Korea·View original on PubMed →
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Original publication title: Oxidative stress due to anesthesia and surgical trauma and comparison of the effects of propofol and thiopental in dogs.
- Species:
- dog
Plain-English summary
A group of dogs undergoing surgery were given either propofol or thiopental to see how these anesthetics affected their bodies during the procedure. Researchers found that both drugs increased oxidative stress (an imbalance between free radicals and antioxidants) during surgery, but the increase was less severe in dogs given propofol compared to those given thiopental. This suggests that propofol may help protect against some of the harmful effects of surgery. More research is needed to fully understand how anesthesia impacts dogs' health during surgery.
People also search for: dog surgery anesthesia effects · propofol vs thiopental for dogs · oxidative stress in dogs after surgery
Abstract
The present study aimed to evaluate the effect of propofol and thiopental on the plasma oxidant-antioxidant profile in dogs undergoing surgery at doses used to induce anesthesia. The plasma total oxidant status (TOS) and oxidative stress index (OSI) levels increased significantly with time in both groups, whereas the plasma total antioxidant status (TAS) levels decreased with time in both groups. The OSI was significantly higher at the end of surgery than before induction of anesthesia in both groups. The TOS and OSI change ratio of propofol group were significantly lower than that of thiopental group. In conclusion, our findings show that propofol has antioxidant effects in dogs. Further studies need to be conducted to demonstrate the exact mechanism of oxidative stress due to anesthesia and surgery in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22198056/