Peer-reviewed veterinary case report
Oxidative stress linked to severity of dog atopic dermatitis
By Kapun, Alja Plevnik et al.·Published in Research in veterinary science·2012·University of Ljubljana·View original on PubMed →
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Original publication title: Oxidative stress markers in canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin condition causing itching and inflammation) showed higher levels of a substance called malondialdehyde (MDA), which indicates oxidative stress, compared to healthy dogs. This study found that the more severe the skin condition was, the higher the MDA levels, suggesting that oxidative damage might play a role in the severity of atopic dermatitis in dogs. However, other antioxidant markers did not show significant differences between the affected and healthy dogs. Understanding these markers could help in managing skin problems in dogs with atopic dermatitis.
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Abstract
There are no data in the veterinary literature relating to oxidative stress in canine atopic dermatitis (CAD). The study aimed to determine levels of oxidative stress markers, plasma malondialdehyde (MDA), total antioxidant capacity (TAC), whole blood glutathione peroxidase (GPX) and erythrocyte superoxide dismutase (SOD), in 15 CAD patients and 17 healthy dogs. A correlation between CADESI (Canine Atopic Dermatitis Extent and Severity Index) score and MDA was also determined. Significantly higher plasma MDA levels were found in patients than in healthy dogs. The significant, highly positive correlation determined between CADESI score and MDA in the patient group indicates an association between the severity of CAD and the extent of oxidative damage to membrane lipids. There were no significant differences in TAC, GPX and SOD between patients and healthy dogs. Our findings suggest that oxidative stress with increased lipid peroxidation could be involved in the pathogenesis of atopic dermatitis in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21601227/