Peer-reviewed veterinary case report
Oxygen level control after dog cardiac arrest protects brain cells
By Lee, Da et al.·Published in Resuscitation·2019·Department of Anesthesiology, United States·View original on PubMed →
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Original publication title: Oximetry-Guided normoxic resuscitation following canine cardiac arrest reduces cerebellar Purkinje neuronal damage.
- Species:
- dog
Plain-English summary
A group of adult beagles that experienced cardiac arrest were studied to see how different oxygen levels during resuscitation affected brain damage. After being revived, some dogs received 100% oxygen while others had their oxygen levels carefully controlled to stay within a normal range. The results showed that the dogs given too much oxygen had significantly more brain cell damage compared to those with controlled oxygen levels. This suggests that keeping oxygen levels normal after a cardiac arrest can help protect the brain from injury.
People also search for: dog cardiac arrest treatment · beagle brain damage recovery · oxygen levels after dog CPR
Abstract
BACKGROUND: Animal studies indicate that maintaining physiologic Olevels (normoxia) immediately after restoration of spontaneous circulation (ROSC) from cardiac arrest (CA) results in less hippocampal neuronal death compared to animals ventilated with 100% O. This study tested the hypothesis that beneficial effects of avoiding hyperoxia following CA are apparent in the cerebellum and therefore not limited to one brain region. METHODS: Adult beagles were anesthetized and mechanically ventilated. Ventricular fibrillation CA was induced by electrical myocardial stimulation and cessation of ventilation. Ten min later, dogs were ventilated with 100% Oand resuscitated using 3 min of open chest CPR followed by defibrillation. Dogs were ventilated for 1 h with either 100% Oor with Otitrated rapidly to maintain hemoglobin Osaturation at 94-96%. FiOwas adjusted in both groups between one and 24 h post-arrest to maintain normoxic PaOof 80-120 mm Hg. Following 24 h critical care, dogs were euthanized and cerebellum analyzed for histochemical measures of neuronal damage and inflammation. RESULTS AND CONCLUSIONS: Hyperoxic resuscitation increased the number of injured Purkinje cells by 278% and the number of activated microglia/macrophages by 18% compared to normoxic resuscitation. These results indicate that normoxic resuscitation promotes favorable histopathologic outcomes in the cerebellum (in addition to hippocampus) following CA/ROSC. These findings emphasize the importance of avoiding unnecessary hyperoxia following CA/ROSC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31063840/