Peer-reviewed veterinary case report
P-glycoprotein levels in intestinal cells of dogs with chronic gut
By Allenspach, K et al.·Published in Journal of comparative pathology·2006·Department of Clinical Veterinary Medicine·View original on PubMed →
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Original publication title: P-glycoprotein expression in lamina propria lymphocytes of duodenal biopsy samples in dogs with chronic idiopathic enteropathies.
- Species:
- dog
Plain-English summary
A group of dogs with chronic intestinal issues, known as inflammatory bowel disease (IBD), had biopsies taken from their intestines to check for a protein called P-glycoprotein (p-gp) that helps with drug processing. After treatment with a steroid called prednisolone, the levels of p-gp increased, suggesting that this treatment may help dogs with IBD respond better. In contrast, dogs that only received a special diet did not show any change in p-gp levels. This study suggests that measuring p-gp levels could help predict how well a dog will respond to steroid treatment for IBD.
People also search for: dog inflammatory bowel disease treatment · prednisolone for dog IBD · dog intestinal biopsy results
Abstract
P-glycoprotein (p-gp) is a transmembrane protein functioning as a drug-efflux pump in the intestinal epithelium. Human patients with inflammatory bowel disease (IBD) who fail to respond to treatment with steroids express high levels of p-gp in lamina propria lymphocytes. The purpose of this study was to investigate p-gp expression in duodenal biopsy samples of dogs with chronic enteropathies and to evaluate the expression of p-gp after treatment with a known inducer of p-gp (prednisolone). Duodenal biopsy samples from 48 dogs were evaluated immunohistochemically with the mouse monoclonal antibody C219 for expression of p-gp in lamina propria lymphocytes. Biopsy samples were available from 15 dogs after treatment with prednisolone and 16 dogs after dietary therapy alone ("elimination diet"). Treatment with prednisolone resulted in an increase in p-gp expression (P=0.005). In contrast, dietary treatment alone produced no significant change in p-gp expression (P=0.59). A low p-gp score before initiation of steroid treatment was significantly associated with a positive response to treatment (P=0.01). These results indicate that lamina propria lymphocyte expression of p-gp is upregulated after prednisolone treatment in dogs with IBD, and that mucosal expression of p-gp may be of value in predicting the response to therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16325844/