Peer-reviewed veterinary case report
p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication.
- Journal:
- Journal of virological methods
- Year:
- 2009
- Authors:
- Capocefalo, A et al.
- Affiliation:
- Facoltà · Italy
Abstract
BoHV-4 replication cycle is dependent on the S-phase of the cell-cycle at the stage of viral DNA synthesis. Because p21 is a rate-limiting regulator of the G1/S-phase transition and up-regulated by DNA-damaging agents, in this study p21 expression in BoHV-4 infected cells was investigated. The p21 promoter was found to be highly activated in a dose- and time-dependent manner following BoHV-4 infection only in cells which are permissive for BoHV-4 replication. Thus p21 expression reports on BoHV-4 replication and could represent a host cell defensive response to infection-associated cellular damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19540267/