Peer-reviewed veterinary case report
P66SHC and ageing: ROS and TOR?
- Journal:
- Aging
- Year:
- 2010
- Authors:
- Pani, Giovambattista
- Affiliation:
- Institute of General Pathology · Italy
- Species:
- rodent
Abstract
Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20689155/