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Peer-reviewed veterinary case report

Pain and Activity Measurements.

Journal:
Methods in molecular biology (Clifton, N.J.)
Year:
2021
Authors:
Molstad, David H H & Bradley, Elizabeth W
Affiliation:
Department of Orthopedics · United States
Species:
rodent

Abstract

Musculoskeletal pain contributes significantly to chronic pain experienced by adults and to health care use. This chapter details several methods to evaluate pain and physical activity in mice that can be applied to preclinical orthopedic models. These methods include the von Frey filament assay that measures mechanical allodynia, open-field activity assays for evaluation of ambulation, and incapacitance measurements to determine static weight bearing.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/32979210/