Peer-reviewed veterinary case report
Pain and inflammation in dogs with nerve pain treated with gabapentin
By Ruel, Hélène L M et al.·Published in PloS one·2020·Department of Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Pain burden, sensory profile and inflammatory cytokines of dogs with naturally-occurring neuropathic pain treated with gabapentin alone or with meloxicam.
- Species:
- dog
Plain-English summary
A group of 29 dogs with neuropathic pain (a type of nerve pain) were treated with either gabapentin alone or gabapentin combined with meloxicam, a common anti-inflammatory medication. Owners reported pain levels using specific questionnaires, and while the dogs showed some improvement in pain scores after treatment, the results were not significantly better than those seen with a placebo. This suggests that while gabapentin and meloxicam may help some dogs, the improvement could also be influenced by the owners' perceptions. Overall, the study indicates that dogs with neuropathic pain may have difficulty managing pain signals, but some relief was noted with treatment.
People also search for: dog neuropathic pain treatment · gabapentin for dogs · meloxicam for dog pain relief
Abstract
Canine neuropathic pain (NeuP) has been poorly investigated. This study aimed to evaluate the pain burden, sensory profile and inflammatory cytokines in dogs with naturally-occurring NeuP. Twenty-nine client-owned dogs with NeuP were included in a prospective, partially masked, randomized crossover clinical trial, and treated with gabapentin/placebo/gabapentin-meloxicam or gabapentin-meloxicam/placebo/gabapentin (each treatment block of 7 days; total 21 days). Pain scores, mechanical (MNT) and electrical (ENT) nociceptive thresholds and descending noxious inhibitory controls (DNIC) were assessed at baseline, days 7, 14, and 21. DNIC was evaluated using ΔMNT (after-before conditioning stimulus). Positive or negative ΔMNT corresponded to inhibitory or facilitatory pain profiles, respectively. Pain scores were recorded using the Client Specific Outcome Measures (CSOM), Canine Brief Pain Inventory (CBPI), and short-form Glasgow Composite Measure Pain Scale (CMPS-SF). Data from baseline were compared to those of sixteen healthy controls. ΔMNT, but not MNT and ENT, was significantly larger in controls (2.3 ± 0.9 N) than in NeuP (-0.2 ± 0.7 N). The percentage of dogs with facilitatory sensory profile was similar at baseline and after placebo (61.5-63%), and between controls and after gabapentin (33.3-34.6%). The CBPI scores were significantly different between gabapentin (CBPI pain and CBPI overall impression) and/or gabapentin-meloxicam (CBPI pain and interference) when compared with baseline, but not placebo. The CBPI scores were not significantly different between placebo and baseline. The concentration of cytokines was not different between groups or treatments. Dogs with NeuP have deficient inhibitory pain mechanisms. Pain burden was reduced after gabapentin and/or gabapentin-meloxicam when compared with baseline using CBPI and CMPS-SF scores. However, these scores were not superior than placebo, nor placebo was superior to baseline evaluations. A caregiver placebo effect may have biased the results.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33253197/