Peer-reviewed veterinary case report
Dog foot pad pain and redness from cancer drug toceranib
By Kim, Eunjoo et al.·Published in Journal of veterinary science·2023·VIP Animal Medical Center KR, South Korea·View original on PubMed →
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Original publication title: Palmar-plantar erythrodysesthesia syndrome resulting from toceranib phosphate in a dog with apocrine gland anal sac adenocarcinoma: a case report.
- Species:
- dog
Plain-English summary
An 11-year-old neutered male Miniature Poodle developed painful, red, and thickened foot pads after starting chemotherapy with toceranib phosphate for anal sac cancer. He also showed signs of depression and loss of appetite, and he had trouble walking. The symptoms went away when the medication was stopped but returned when it was given again. This case highlights that while rare, foot pad issues can occur with toceranib treatment, and pet owners should be aware of these potential side effects. The dog’s symptoms improved after discontinuing the medication.
People also search for: dog foot pad problems after chemotherapy · Miniature Poodle cancer treatment side effects · toceranib phosphate dog symptoms
Abstract
An 11-year-old neutered male Miniature Poodle with a stage 3 apocrine gland adenocarcinoma was started on chemotherapy with toceranib phosphate after surgery. Beginning on day 10 of toceranib, the dog's foot pads became erythematous and hyperkeratinized. The dog complained of pain, inability to walk, depression, and loss of appetite. The symptoms resolved when toceranib was discontinued and reappeared when toceranib was resumed. Grade 3 palmar-plantar erythrodysesthesia was identified as an adverse event of toceranib based on the VCOG-CTCAE and Naranjo scale. Although very rare in veterinary medicine, clinicians should consider that palmar-plantar erythrodysesthesia can occur after toceranib administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37904638/