Peer-reviewed veterinary case report
Dog with high calcium caused by benign kidney tumor treatment
By Gajanayake, Isuru et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2010·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Paraneoplastic hypercalcemia in a dog with benign renal angiomyxoma.
- Species:
- dog
Plain-English summary
An 11-year-old male neutered Collie was brought in because he was drinking a lot of water and urinating frequently. Tests showed he had high calcium levels and a mass in his right kidney. The mass was surgically removed, and it turned out to be a benign tumor called a renal angiomyxoma. After the surgery, his calcium levels returned to normal, and he stopped drinking excessively and urinating a lot. One year later, he was doing well and had no more symptoms.
People also search for: dog drinking a lot of water · Collie kidney tumor · hypercalcemia in dogs treatment
Abstract
An 11-year-old, male, neutered crossbred Collie dog was presented for a history of polydipsia and polyuria. Diagnostic investigations revealed total and ionized hypercalcemia and an increased concentration of parathyroid hormone-related peptide. Abdominal ultrasonography and contrast-enhanced computed tomography of the abdomen revealed a right-sided, cystic-appearing renal mass. Cytological examination of ultrasound-guided aspirates of the mass revealed high numbers of spindle cells. The mass was removed en bloc via an ureteronephrectomy. Histopathological examination of the mass revealed neoplastic spindle cells in loosely packed and interlacing streams within a myxomatous stroma. Immunohistochemical examination with vimentin, von Willebrand Factor, and alpha-smooth muscle actin confirmed the mass to be a renal angiomyxoma. A minority of the neoplastic spindle cells showed positive cytoplasmic parathyroid hormone-related peptide immunostaining. The hypercalcemia resolved following surgery, and the parathyroid hormone-related peptide concentration returned to within the reference interval. The dog was no longer polydipsic or polyuric 1 year following surgery. The present report describes a previously unreported renal neoplasm causing paraneoplastic hypercalcemia and highlights the possibility of paraneoplastic hypercalcemia being caused by a benign neoplasm.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20807942/