Peer-reviewed veterinary case report
Dog with haemophagocytic histiocytic sarcoma causing anemia and low
By Soare, T et al.Ā·Published in Journal of comparative pathologyĀ·2012Ā·Department of Veterinary Pathology, United KingdomĀ·View original on PubMed ā
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Original publication title: Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old neutered male flat-coated retriever was diagnosed with a serious condition called haemophagocytic histiocytic sarcoma (HHS), which caused low protein levels and anemia. The tumor cells were found to be destroying red blood cells and albumin, a protein in the blood, while also producing a substance called interleukin-6 that contributed to the dog's symptoms. Unfortunately, this type of cancer is aggressive and can lead to severe health issues. Treatment options may vary, but it's crucial to discuss the best approach with your veterinarian for managing this condition.
People also search for: dog anemia symptoms Ā· flat-coated retriever cancer treatment Ā· haemophagocytic histiocytic sarcoma in dogs
Abstract
A case of metastatic splenic haemophagocytic histiocytic sarcoma (HHS) in a 6-year-old neutered male flat-coated retriever is described. The main clinical findings were hypoalbuminaemia and regenerative anaemia. The diagnosis was based on histological features and expression of CD11d by the neoplastic cells. Tumour cells were shown to produce interleukin (IL)-6, to phagocytose erythrocytes and to take up albumin, as demonstrated by immunohistochemistry and ultrastructural examination. Quantitative polymerase chain reaction identified increased IL-6 gene expression in affected organs. These findings suggest that neoplastic cells are responsible for the clinical features of HHS, by removing erythrocytes and albumin from the blood and releasing cytokines, such as IL-6.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21741052/