Peer-reviewed veterinary case report
PARK2/Parkin becomes critical when DNM1L/Drp1 is absent.
- Journal:
- Autophagy
- Year:
- 2015
- Authors:
- Roy, Madhuparna et al.
- Affiliation:
- a Department of Cell Biology · United States
Abstract
Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25715097/