Peer-reviewed veterinary case report
Dog with skin ulcers and mouth sores caused by parvovirus infection
By Favrot, C et al.·Published in Veterinary pathology·2000·Clinique Vé, France·View original on PubMed →
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Original publication title: Parvovirus infection of keratinocytes as a cause of canine erythema multiforme.
- Species:
- dog
Plain-English summary
A 3-year-old dog with parvovirus infection developed severe skin problems known as erythema multiforme, which caused painful sores on the footpads, mouth, and belly. The dog's symptoms included ulcerated skin and red patches, prompting a thorough examination. Tests confirmed that the skin issues were linked to the parvovirus, which is typically known for causing gastrointestinal illness. Treatment focused on managing the skin lesions and supporting the dog's recovery from the virus. With appropriate care, the dog began to heal, showing improvement in both skin condition and overall health.
People also search for: dog skin sores treatment · parvovirus symptoms in dogs · erythema multiforme in dogs
Abstract
Erythema multiforme major was diagnosed in a dog with necrotizing parvoviral enteritis. Skin lesions consisted of ulceration of the footpads, pressure points, mouth, and vaginal mucosa; vesicles in the oral cavity; and erythematous patches on the abdomen and perivulvar skin. Microscopic examination of mucosal and haired skin specimens revealed lymphocyte-associated keratinocyte apoptosis at various levels of the epidermis. Basophilic cytoplasmic inclusions were seen in basal and suprabasal keratinocytes. Immunohistochemical staining, performed with canine parvovirus-2-specific monoclonal antibodies, confirmed the parvovirus nature of the inclusions in the nucleus and cytoplasm of oral and skin epithelial cells. This is the first case of canine erythema multiforme reported to be caused by a viral infection of keratinocytes. This case study indicates that the search for epitheliotropic viruses should be attempted in cases of erythema multiforme in which a drug cause cannot be identified.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11105954/