Peer-reviewed veterinary case report
How canine parvovirus spreads in puppies and causes illness
By Meunier, P. C. et al.·Published in Veterinary Pathology·1985·Department of Veterinary Pathology and the James A. Baker Institute, New York State Veterinary College, Cornell University, Ithaca, N.Y., United States·View original on Crossref →
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Original publication title: Pathogenesis of Canine Parvovirus Enteritis: The Importance of Viremia
- Species:
- dog
Plain-English summary
A group of 22 nine-week-old beagle puppies were studied after being exposed to canine parvovirus, a serious virus that can cause vomiting and diarrhea. About 30% of the puppies showed symptoms like fever, depression, vomiting, and diarrhea, with those injected directly into the bloodstream showing signs about two days earlier than those given the virus orally. Most puppies had a drop in certain white blood cells, and while only one puppy died, the severity of their illness was linked to how long the virus was present in their blood. The puppies that showed symptoms had higher levels of the virus in their blood and stool compared to those that didn’t get sick.
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Abstract
The clinical signs, hematologic changes, serum and fecal virus titers, specific antibody production and the occurrence of histologic lesions were studied in 22 nine-week-old seronegative beagle dogs inoculated by the oral and intravenous route with canine parvovirus. Approximately 30% of the dogs had clinical signs of pyrexia, depression, vomiting, and diarrhea irrespective of the route of inoculation. Events in the dogs inoculated intravenously preceded those in dogs inoculated orally by approximately two days. Only one dog died. Lymphopenia was the most consistent hematologic change. Viremia always preceded the initiation of fecal virus shedding. Viral titers in the serum and feces were significantly greater in symptomatic dogs compared to asymptomatic dogs. Termination of the plasma viremia coincided with the onset of the humoral immune response, but viremia persisted one day longer in symptomatic dogs. The severity of lymphoid tissue and intestinal infection, assessed by tissue immunofluorescence and histology, was also greater in symptomatic dogs. The severity of intestinal disease was highly correlated with the magnitude and duration of viremia.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/030098588502200110