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Peer-reviewed veterinary case report

Pathogenic differences between North American and Latin American strains of Histoplasma capsulatum var. capsulatum in experimentally infected mice.

Journal:
Journal of clinical microbiology
Year:
2004
Authors:
Durkin, Michelle M et al.
Affiliation:
MiraVista Diagnostics/MiraBella Technologies · United States
Species:
rodent

Abstract

Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/15365047/