Peer-reviewed veterinary case report
Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2015
- Authors:
- Tamura, Tomokazu et al.
- Affiliation:
- Department of Disease Control · Japan
Abstract
A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25391535/