Peer-reviewed veterinary case report
Long-term medroxyprogesterone use linked to serious health issues
By Keskin, Abdulkadir et al.·Published in Journal of feline medicine and surgery·2009·Department of Obstetrics and Gynecology·View original on PubMed →
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Original publication title: Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen.
- Species:
- cat
Plain-English summary
An 11-year-old female domestic shorthair cat was brought to the vet because she had a reduced appetite, was drinking and urinating more than usual, had a swollen belly, and a lump in her breast. After tests, the vet diagnosed her with a serious infection in her uterus (pyometra) and found other issues like ovarian cysts and mammary tumors. To treat her, the vet performed surgery to remove her uterus and ovaries, as well as the mammary mass. The long-term use of a hormone medication may have contributed to these health problems.
People also search for: cat reduced appetite · cat drinking more than usual · cat mammary tumor treatment · pyometra in cats · ovarian cysts in cats
Abstract
In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH-P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH-P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19058986/