Pathology and evaluation of immunohistochemical expression of tumour protein 63 (p63) in corneal squamous cell carcinoma in a dog

Abstract

In the present study, an exophytic mass on the corneal surface in a six-year-old male Rottweiler is described. Histopathologically, neoplastic cells appeared round to polygonal with vesicular to hyperchromatic nuclei and scanty to moderate eosinophilic cytoplasm. There was infiltration of neoplastic cells into underlying stroma as well as the ulcerated fibrovascular tissue. Based on the histopathological findings, the tumor was identified as corneal squamous cell carcinoma. Immunohistochemical expression of tumour protein 63 (p63) was evaluated in the tumour and a strong expression was detected. Squamous cell carcinoma should always be a differential whenever an ulcerated mass is found in the ocular and adnexal surface1