Peer-reviewed veterinary case report
Factors linked to high-grade mast cell tumors in dogs
By Reynolds, Benjamin D et al.·Published in Veterinary and comparative oncology·2019·Department of Oncology, Australia·View original on PubMed →
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Original publication title: Patient and tumour factors influencing canine mast cell tumour histological grade and mitotic index.
- Species:
- dog
Plain-English summary
A study looked at factors that might affect the severity of mast cell tumors (MCTs) in dogs. They found that Shar Peis were more likely to have high-grade MCTs, while Pugs and Golden Retrievers were less likely to develop severe forms of these tumors. The location of the tumor also mattered; those found in the inguinal area (near the groin) were more often high-grade. However, the dog's age, gender, and whether they were neutered didn't seem to impact the tumor's grade. Understanding these factors can help veterinarians better assess and treat MCTs in dogs.
People also search for: dog mast cell tumor treatment · high-grade mast cell tumor in Shar Pei · dog tumor location significance
Abstract
The aim of this study was to identify patient and tumour factors most frequently associated with high histological grades of canine mast cell tumours (MCTs). Search criteria in a shared database of multiple Animal Referral Hospital locations within Australia generated 400 canine MCTs in 286 patients. Patient and tumour data were extrapolated and the association between a tumour being histologically high grade and patient and tumour factors, including: patient breed, patient gender and neuter status, patient age at MCT excision, tumour location and tumour size was assessed using univariate analysis. The study consisted of 90 (21.9%) tumours meeting histological high-grade criteria. Shar peis were the most likely breed to have high grade MCTs, whereas the Pug and the Golden Retriever were the least likely breeds to develop high-grade MCTs. No significant difference in risks could be established between the age at which the tumour was excised, or the gender and neuter status of patients. MCTs of the inguinal region were the most likely single location to be high grade. Tumour size did not influence the likelihood of a tumour being high grade or low grade. The results of this study suggest that patient and tumour factors may play a role in the histological grades of canine MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30891882/