Peer-reviewed veterinary case report
Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2024
- Authors:
- Buck, Jessica et al.
- Affiliation:
- Telethon Kids Institute · Australia
- Species:
- rodent
Abstract
Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38676795/