Peer-reviewed veterinary case report
Patient-Derived Xenograft Models for Leukemias.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2024
- Authors:
- Brown, Fiona C & Carmichael, Catherine L
- Affiliation:
- The Walter and Eliza Hall Institute of Medical Research · Australia
- Species:
- rodent
Abstract
Patient-derived xenograft (PDX) modeling is a valuable tool for the study of leukemia pathogenesis, progression, and therapy response. Engraftment of human leukemia cells occurs following injection into the tail vein (or retro-orbital vein) of preconditioned immunocompromised mice. Injected mice are maintained in a sterile and supportive housing environment until leukemia engraftment is observed, at which time studies such as drug treatments or leukemia sampling can occur. Here, we outline a method for generating PDXs from Acute Myeloid Leukemia (AML) patient samples using tail vein injection; however it can also be readily applied to T- and B- Acute Lymphoblastic Leukemia (ALL) samples.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38676794/