Peer-reviewed veterinary case report
Oral cancer grade and PCNA levels predict dog survival after surgery
By Mestrinho, L A et al.·Published in Veterinary and comparative oncology·2017·CIISA·View original on PubMed →
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Original publication title: PCNA and grade in 13 canine oral squamous cell carcinomas: association with prognosis.
- Species:
- dog
Plain-English summary
A dog with oral squamous cell carcinoma (a type of mouth cancer) was treated with surgery to remove the tumor, which had invaded the bone. The surgery involved removing the tumor along with a margin of healthy tissue to ensure all cancer cells were eliminated. After two years, dogs with more aggressive tumors (grade 3) had a median survival time of about 138 days, while those with less aggressive tumors (grade 2) lived longer without signs of cancer returning. The study found that higher levels of a specific marker (PCNA) were linked to a worse prognosis, indicating that the tumor's grade and PCNA levels can help predict outcomes for dogs with this condition.
People also search for: dog mouth cancer treatment · oral squamous cell carcinoma in dogs · prognosis for dog cancer surgery
Abstract
This study evaluated the prognosis factors of age, tumour size, anatomic location, histological grade and proliferating cell nuclear antigen (PCNA) expression in 13 dogs with oral squamous cell carcinoma (OSCC) with bone invasion and without signs of lymph node or distant metastasis. All animals were treated with radical excision performed with at least 1 cm margin, based on computed tomography images. In the 2-year follow-up, median disease-free survival was 138 days for dogs with grade 3 tumours and was not reached for those with grade 2 tumours. Grade 3 tumours and PCNA labelling index ≥65% were related with a shorter disease-free survival time and consequently poor prognosis (p = 0.003 and p = 0.034, respectively). Mean PCNA labelling index was significantly higher in recurrent cases (p = 0.011). Histological grade and PCNA expression may be important prognosis factors in canine OSCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25524719/