Peer-reviewed veterinary case report
PDE4D and miR-203 as new blood tests for dog skin allergy
By Kaur, Gagandeep et al.·Published in Molecular biology reports·2024·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: PDE4D and miR-203 are promising biomarkers for canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A study found that dogs with atopic dermatitis (CAD), a common itchy skin condition, showed higher levels of a specific gene (PDE4D) in their blood compared to healthy dogs and those with other skin issues. This suggests that PDE4D could help vets diagnose CAD more accurately. Additionally, another marker called miR-203 was identified as a general indicator of skin inflammation, which could help differentiate CAD from other skin problems. While these findings are promising, more research is needed to confirm their effectiveness in diagnosing CAD in dogs.
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Abstract
BACKGROUND: Canine atopic dermatitis (CAD) is a common genetically predisposed, inflammatory, and pruritic skin disorder that affects dogs globally. To date, there are no specific biomarkers available to diagnose CAD, and the current diagnosis is based on a combination of criteria including patient history, clinical signs, and exclusion of other relevant differential diagnoses. METHODS AND RESULTS: We examined the gene expression of phosphodiesterase 4D (PDE4D) in peripheral blood mononuclear cells (PBMCs), as well as miR-203 and miR-483 in plasma, in three groups: healthy dogs, CAD dogs, and other inflammatory pruritic skin diseases (OIPSD) such as pemphigus foliaceus, scabies, cutaneous lymphoma, and dermatophytosis. Our results showed that PDE4D gene expression in the CAD group is statistically higher compared to those in the healthy and OIPSD groups, suggesting PDE4D may be a specific marker for CAD. Nevertheless, no correlation was found between PDE4D gene expression levels and the lesion severity gauged by CAD severity index-4 (CADESI-4). We also showed that miR-203 is a generic marker for clinical dermatitis and differentiates both CAD and OIPSD inflammatory conditions from healthy controls. CONCLUSIONS: We show that PDE4D is a potential marker to differentiate CAD from non-atopic healthy and OIPSD while miR-203 may be a potential marker for general dermatologic inflammation. Future study of PDE4D and miR-203 on a larger scale is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38734860/