Peer-reviewed veterinary case report
PEG-amino acid-przewaquinone a conjugations: Synthesis, physicochemical properties and protective effect in a rat model of brain ischemia-reperfusion.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2020
- Authors:
- Wang, Minghui et al.
- Affiliation:
- School of Pharmacy · United States
- Species:
- rodent
Abstract
A total of 21 PEG-przewaquinone A conjugations with high drug loading ability, good water solubility and in vivo slow-release quality were obtained by conjugating przewaquinone A with PEG through amino acids and tripeptides spacers respectively. Notably, compound 3a can obviously reduce the brain ischemia-reperfusion damage dose-dependently in a rat model, which indicated the efficacy of our PEG prodrug strategy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31784321/