Peer-reviewed veterinary case report
Pelger-Huet anomaly causing unusual white blood cells in a cat
By Deshuillers, Pierre et al.·Published in Veterinary clinical pathology·2014·Department of Comparative Pathobiology, United States·View original on PubMed →
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Original publication title: Pelger-Huët anomaly in a cat.
- Species:
- cat
Plain-English summary
A 14-year-old spayed female Domestic Shorthair cat was brought in for treatment of hyperthyroidism and was found to have unusual white blood cells. About half of her neutrophils (a type of white blood cell) looked different, with band-shaped nuclei, which indicated a condition called Pelger-Huët anomaly. This condition is usually harmless and doesn't cause any symptoms, and the cat showed no signs of illness related to inflammation. After further testing, the diagnosis was confirmed, and she continued her treatment for hyperthyroidism without any complications from the anomaly.
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Abstract
A 14-year-old, spayed female Domestic Shorthair cat was referred to the Purdue University Veterinary Teaching Hospital (PUVTH) for iodine 131 treatment of hyperthyroidism. Upon arrival, a biochemistry profile and a CBC were performed. Approximately 50% of the neutrophils and all the eosinophils observed were hyposegmented with a mature, condensed chromatin pattern. Nuclei had a band to "dumbbell" shape, and rarely a round shape, suggesting a Pelger-Huët anomaly or a pseudo Pelger-Huët. Based on both a negative FeLV and FIV tests, the absence of any clinical signs to support an inflammatory process, and the persistence of this granulocytic morphology 6 months after its previous admission to the PUVTH, a diagnosis of Pelger-Huët anomaly was established in this cat.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25115222/