Peer-reviewed veterinary case report
Pelger-Huet anomaly found in two related mixed-breed dogs
By Vale, André M et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Veterinary Hospital, Brazil·View original on PubMed →
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Original publication title: Pelger-Huët anomaly in two related mixed-breed dogs.
- Species:
- dog
Plain-English summary
A 6-month-old male mixed-breed dog was brought to the vet because of a lump under the skin on his back. Blood tests showed some unusual white blood cells, which led to further examination. The dog's mother also had similar blood cell changes, confirming that both had a genetic condition called Pelger-Huët anomaly, which affects the shape of certain white blood cells. While this condition is not typically harmful, it can be important for future health monitoring. The dog did not require any specific treatment and continued to be monitored.
People also search for: dog lump under skin · mixed-breed dog blood test results · Pelger-Huët anomaly in dogs
Abstract
A 6-month-old male mixed-breed dog weighing 12.6 kg weight was presented for evaluation of a subcutaneous nodule on the dorsum. The medical history indicated trimethoprim-sulfamethoxazole treatment 2 months before presentation at the veterinary hospital. The initial complete blood cell count (CBC) results included an apparent left shift. Microscopic examination of a blood smear (Panoptic stain) revealed granulocytes with hyposegmented nuclei, coarse mature chromatin, and a nuclear shape varying from round to bilobed (pince-nez) or slightly indented. Occasional neutrophils and eosinophils had typical segmentation of nuclei. Abnormalities were not present in limited serum biochemical testing. The CBC was repeated 17 and 120 days later, and the results were similar to those observed in the first examination. The parents of the patient were located, and a CBC was performed on both animals. The dam, but not the sire, had nuclear hyposegmentation of granulocytes, confirming the diagnosis of Pelger-Huët anomaly.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908340/