Peer-reviewed veterinary case report
Dog with liver peliosis and fibrosis linked to infection
By Robveille, Cynthia et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2025·Comparative Medicine Institute, United States·View original on PubMed →
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Original publication title: Peliosis hepatis and hepatic fibrosis in a dog infected with multiplespecies.
- Species:
- dog
Plain-English summary
A 13-year-old spayed female dog was brought in with symptoms like low red blood cell count, low white blood cell count, and liver problems. A liver biopsy showed severe liver damage and unusual blood vessel growth in the liver, which can happen with certain infections. Despite treatment, the dog's condition worsened over nine months, leading to severe liver failure and ultimately euthanasia. This case highlights how infections can lead to serious liver issues in dogs.
People also search for: dog liver disease symptoms · dog anemia treatment · spayed female dog liver problems
Abstract
A 13-y-old, spayed female dog had regenerative anemia, lymphopenia, hypoalbuminemia, and elevated hepatic biochemical parameters. Liver biopsy revealed hepatic peliosis (hepatic sinusoidal angiectasis), frequently associated with perisinusoidal fibrosis. The dog was seroreactive toantigens by indirect fluorescent antibody assays, and quantitative PCR from blood identifiedsubsp.genotype II. The dog was euthanized 9 mo later because of acute decompensation. Autopsy revealed icteric adipose tissues, end-stage liver, and abdominal effusion. Microscopically, there was marked mixed-cell chronic hepatitis with hepatocellular loss, nodular hepatocellular regeneration, and capillary proliferation. Retrospective molecular testing documentedandDNA in the dog's blood at 2 or more times during liver disease progression.DNA was also amplified and sequenced from the autopsy sample of liver. Our case emphasizes thatinfection may be associated with hepatic peliosis and end-stage liver in dogs and expands the spectrum ofspecies that potentially play a role in canine hepatic diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39773236/