Peer-reviewed veterinary case report
Dog with extreme agitation and vomiting after pemoline poisoning
By Cudia, S P et al.·Published in Journal of the American Veterinary Medical Association·1998·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Pemoline toxicosis in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old German Short-haired Pointer was brought to the vet after showing extreme agitation, hyperactivity, and vomiting within a day of eating about 750 mg of pemoline, a stimulant. The dog was very restless, had a fast heartbeat, was disoriented, and had dilated pupils, all signs of serious overstimulation from the drug. The vet took blood and urine samples to check for toxins and gave the dog several sedatives to calm him down, along with activated charcoal and fluids. Thankfully, the dog started to improve and was back to normal about 72 hours after the incident.
People also search for: dog vomiting after eating stimulant · German Short-haired Pointer agitation treatment · pemoline poisoning in dogs
Abstract
A 3-year-old German Short-haired Pointer was examined because of extreme agitation, hyperactivity, and vomiting that began within 24 hours after ingestion of approximately 750 mg of pemoline, a CNS stimulant. On physical examination, the dog was agitated, tachycardic, hyper-responsive, pyrectic, disoriented, and had mydriasis. These signs were consistent with excessive stimulation of the CNS and sympathomimetic effects resulting from pemoline toxicosis. Serial blood and urine samples were obtained, and toxicologic analyses were performed. Extrapolation of the plasma pemoline concentration 32 hours after ingestion provided an estimated peak plasma concentration of 368 micrograms/ml, dramatically higher than a therapeutic concentration of 1.7 to 7.0 micrograms/ml reported for children. Several sedatives were administered intravenously to alleviate clinical signs and to allow administration of activated charcoal (PO) and fluids (IV). Clinical signs resolved approximately 72 hours after ingestion of pemoline.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9426782/