Peer-reviewed veterinary case report
Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow.
- Year:
- 2025
- Authors:
- Earley S.
- Affiliation:
- Department of Pharmacology and Physiology · United States
Abstract
Intrinsic control of cerebral blood flow in response to intravascular pressure is traditionally attributed to smooth muscle cells in arterioles. However, in this issue of <i>Science Signaling</i>, Ferris <i>et al.</i> demonstrate that capillary constriction is caused by pressure-induced depolarization of pericytes, mural cells that encircle capillaries, and is mediated by TRPC3 cation channels, identifying the channel as critical for fine-tuning brain perfusion.
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Search related cases →Original publication: https://europepmc.org/article/MED/40299957