Peer-reviewed veterinary case report
Pain medicines vedaprofen and tramadol do not affect bleeding
By Brondani, Juliana T et al.·Published in Journal of feline medicine and surgery·2009·Department of Veterinary Surgery and Anesthesiology, Brazil·View original on PubMed →
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Original publication title: Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats.
- Species:
- cat
Plain-English summary
A group of 40 adult female cats undergoing surgery had either vedaprofen, tramadol, a combination of both, or a placebo given to them before and after the procedure. The goal was to see if these medications affected blood clotting, organ function, or caused any gastrointestinal issues. After the surgery, the cats showed no significant changes in their blood tests or bleeding times, and vomiting only occurred after receiving morphine for pain relief. The cats given tramadol or the combination of tramadol and vedaprofen did show mild euphoria, but overall, the medications did not negatively impact their recovery.
People also search for: cat surgery recovery · tramadol for cats pain · vedaprofen side effects in cats
Abstract
A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5mg/kg PO (V), tramadol 2mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19168382/