Peer-reviewed veterinary case report
T cell changes in blood and gut of dogs with chronic intestinal
By Agulla, Beatriz et al.·Published in Journal of veterinary internal medicine·2024·Department Medicina i Cirurgia Animals, Spain·View original on PubMed →
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Original publication title: Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy.
- Species:
- dog
Plain-English summary
A group of dogs with chronic inflammatory enteropathy (CIE) showed signs of intestinal inflammation, which can cause symptoms like vomiting, diarrhea, and weight loss. Researchers found that these dogs had higher levels of certain immune cells in their blood compared to healthy dogs, indicating an immune response to the inflammation. They also noted changes in the types of immune cells present in the intestines. These findings suggest that specific immune markers in the blood could help diagnose and monitor CIE in dogs. Treatment options typically include dietary changes and medications to manage inflammation.
People also search for: dog chronic diarrhea treatment · dog vomiting and weight loss · inflammatory bowel disease in dogs · dog immune system issues
Abstract
BACKGROUND: Dysregulated T lymphocyte response is thought to play a key role in chronic intestinal inflammation (CIE). OBJECTIVES: To evaluate the presence of changes in peripheral and intestinal T lymphocyte subsets and to describe potential immune and inflammatory biomarkers in dogs with CIE. ANIMALS: Sixteen healthy dogs and 26 dogs were diagnosed with CIE. METHODS: Prospective case-control study evaluating peripheral and intestinal T lymphocytes using flow cytometry and inflammatory markers obtained from complete blood cell counts. RESULTS: Dogs with CIE had higher peripheral activated T helper (Th) lymphocytes (87/μL [18-273] CIE, 44/μL [16-162] healthy control (HC, P = .013) and regulatory T cells (Treg; 108/μL [2-257] CIE, 34/μL [1-114] HC, P = .004). In the intestinal epithelium, CIE dogs presented lower percentages of Th (4.55% [1.75-18.67] CIE, 8.77% [3.79-25.03] HC, P = .002), activated Th cells (0.16% [0.02-0.83] CIE, 0.33% [0.05-0.57] HC, P = .03) and CD4/CD8 ratio (0.08 [0.02-0.39] CIE, 0.21 [0.07-0.85] HC, P = .003). Conversely, higher percentage of activated T cytotoxic cells (20.24% [3.12-77.12] CIE, 12.32% [1.21-39.22] HC, P = .04) and interferon-gamma (IFN-γ) producing T lymphocytes (7.36% [0.63-55.83] CIE, 1.44% [0.00-10.56] HC, P = .01) within the epithelium was observed. In the lamina propria the percentage of Treg lymphocytes was higher (6.02% [1.00-21.48] CIE, 3.52% [0.18-10.52] HC, P = .02). CONCLUSIONS AND CLINICAL IMPORTANCE: Systemic and intestinal immune alterations occur in dogs with CIE suggesting that blood IFN-γ producing T lymphocytes and the systemic immune-inflamation index (SII) could potentially serve as biomarkers for the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38472110/