Peer-reviewed veterinary case report
Blood and urine oxidative stress markers in dogs
By Tusa, Nicole V et al.·Published in Journal of veterinary internal medicine·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis.
- Species:
- dog
Plain-English summary
A group of 15 dogs with acute pancreatitis (AP) showed higher levels of oxidative stress markers compared to 9 healthy dogs. Symptoms of AP can include vomiting, abdominal pain, and lethargy. The study measured various substances in the blood and urine to assess the dogs' condition, but it found that these oxidative stress markers did not directly predict how severe the pancreatitis was or how long the dogs would need to stay in the hospital. While the findings suggest that oxidative stress is present in dogs with AP, the exact impact on treatment or recovery remains unclear.
People also search for: dog pancreatitis symptoms · dog vomiting treatment · acute pancreatitis in dogs · oxidative stress in dogs
Abstract
BACKGROUND: Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally-occurring AP. HYPOTHESIS OR OBJECTIVES: Evaluate measures of oxidant status in dogs with AP and explore whether these measures correlate with AP severity. ANIMALS: Fifteen dogs with AP and 9 control dogs. METHODS: Prospective, controlled observational study. Plasma reactive metabolite (RM) concentrations, antioxidant potential (AOP), and urinary Fisoprostane concentrations were measured in AP dogs and healthy controls. Severity of AP was assessed by length of hospitalization and 3 disease severity indices: canine acute pancreatitis severity (CAPS), modified canine activity index (M-CAI), and the acute patient physiologic and laboratory evaluation score (APPLE). RESULTS: Reactive metabolite (RM) concentrations (median, 65 relative fluorescent units [RFU]/μL; range, 20-331 RFU/μL) and RM:AOP (median, 7; range, 4-109) were higher in AP dogs than healthy controls (median RM, 25 RFU/μL; range, 16-41 RFU/μL; median RM:AOP, 4; range, 2-7; P < .001 for both comparisons). Reactive metabolite (r = 0.603, P = .08) and RM:AOP (r = 0.491, P = .06) were not correlated with the duration of hospitalization or disease severity indices evaluated. However, disease severity indices did not predict mortality in our study. Normalized urine 2,3-dinor-8-iso-prostaglandin F2α concentrations were correlated with C-reactive protein (CRP; r = 0.491, P = .03), canine specific pancreatic lipase (Spec cPL; r = 0.746, P = .002), and CAPS (r = 0.603, P = .02). CONCLUSIONS AND CLINICAL IMPORTANCE: Oxidant status is altered in dogs with naturally occurring AP, but the clinical relevance of this finding is unknown.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36086902/