Peer-reviewed veterinary case report
Peripheral neuroblastoma tumors in young dogs' abdomens
By Arenas-Gamboa, A M et al.·Published in Journal of comparative pathology·2014·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Peripheral neuroblastomas in dogs: a case series.
- Species:
- dog
Plain-English summary
A group of young dogs, mostly Labrador retrievers and boxers, were diagnosed with peripheral neuroblastoma, a rare type of tumor in the abdomen. These tumors were found as large masses and were made up of abnormal nerve cells. The dogs were around 3 years old when diagnosed, and some showed specific cell patterns under the microscope that indicated the tumors were neurogenic (related to nerve cells). Treatment details weren't specified, but recognizing the signs early can help in managing this serious condition.
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Abstract
The peripheral neuroblastic tumours (PNTs) include neuroblastoma, ganglioneuroblastoma and ganglioneuromas. These subtypes reflect a spectrum of differentiation of progenitor cells of the sympathetic nervous system from tumours with predominant undifferentiated neuroblasts to those consisting of neuronal cell bodies that are well differentiated. Peripheral neuroblastoma is a tumour composed of neuroblastic cells with no or limited neuronal differentiation. In dogs, peripheral neuroblastoma is rare. The present report documents nine cases of canine peripheral neuroblastoma, the majority occurring as large masses in the craniodorsal abdominal cavity of young dogs (mean age of 3 years at diagnosis). Microscopically, all of the masses consisted of round to oval cells with a scant cytoplasm and hyperchromatic nuclei. Homer-Wright rosettes and pseudorosettes were evident in three of the nine cases. Neoplastic cells were immunoreactive in varying degrees to S100, neuron-specific enolase, synaptophysin, chromogranin A, tyrosine hydroxylase (one case) and were negative for vimentin, cytokeratin, CD3 and CD79a, indicating a neurogenic nature. Four of the nine cases occurred in Labrador retrievers (44%) and two (22%) in boxers, suggesting a possible breed predisposition.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24456749/