Peer-reviewed veterinary case report
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.
- Journal:
- Nature medicine
- Year:
- 2004
- Authors:
- Harman, Fred S et al.
- Affiliation:
- Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis · United States
- Species:
- rodent
Abstract
Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15048110/