Peer-reviewed veterinary case report
Persistent Bilateral Mydriasis Associated With a Pituitary Adenoma in a Horse.
- Journal:
- Journal of equine veterinary science
- Year:
- 2020
- Authors:
- Allnoch, Lisa et al.
- Affiliation:
- Department of Pathology · Germany
- Species:
- horse
Plain-English summary
A 23-year-old crossbred warmblood gelding had severe eye problems, including very large pupils and decreased vision, which were linked to a condition called pituitary pars intermedia dysfunction. After ten years of these issues getting worse and not responding to treatment, the horse was humanely put down. A thorough examination after death confirmed that the horse had a pituitary adenoma, which is a type of tumor, along with damage to important nerves related to vision. The eye problems were similar to those seen in a condition affecting the area around the sinuses in the brain. Unfortunately, despite the treatments, the horse's condition did not improve.
Abstract
Severe bilateral mydriasis and bilaterally decreased vision were observed in a 23-year-old crossbred warmblood gelding with a history of pituitary pars intermedia dysfunction. Ten years after the onset of clinical signs, it was killed humanely because of worsening of clinical signs and loss of therapeutic responsiveness. Postmortem examination of the head was performed to confirm the suspected pituitary neoplasm and to investigate secondary oculomotor lesions. Pathomorphologic examination revealed an expansile space-occupying pituitary adenoma and degenerative changes in the preganglionic oculomotor nerve, ciliary ganglion, and optic chiasm. The ocular clinical findings share features of a cavernous sinus syndrome.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31952640/