Peer-reviewed veterinary case report
Persistent hypoglycemia associated with lipid storage myopathy in a paint foal.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2018
- Authors:
- Pinn, Toby L et al.
- Affiliation:
- Department of Clinical Sciences · United States
- Species:
- horse
Plain-English summary
A 12-hour-old Paint filly was brought in because she was weak and not very alert after birth. Even after receiving sugar through an IV, her blood sugar levels stayed low, and tests showed problems with her muscle and liver enzymes. After she passed away, a postmortem examination revealed that she had a condition called lipid storage myopathy, which is similar to a genetic disorder known as multiple acyl-CoA dehydrogenase deficiency (MADD). This case highlights that lipid storage myopathy should be considered when foals show ongoing weakness and low blood sugar. Unfortunately, the treatment did not work, and the filly did not survive.
Abstract
A 12-hours-old Paint filly was examined because of weakness and dull mentation after birth. Despite IV administered dextrose, the foal remained persistently hypoglycemic with increase in serum activity of muscle and liver enzymes. A postmortem diagnosis of lipid myopathy most similar to multiple acyl-CoA dehydrogenase deficiency (MADD) was confirmed by findings of myofiber lipid accumulation, elevated urine organic acids, and serum free acylcarnitines with respect to control foals. This report details a case of equine neonatal lipid storage myopathy with many biochemical characteristics of MADD. Lipid storage myopathies should be included as a differential diagnosis in foals with persistent weakness and hypoglycemia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29957835/