Peer-reviewed veterinary case report
Miniature Poodle with lasting low cortisol after short trilostane
By Ramsey, I K et al.·Published in Australian veterinary journal·2008·Faculty of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Persistent isolated hypocortisolism following brief treatment with trilostane.
- Species:
- dog
Plain-English summary
A 12-year-old male neutered Miniature Poodle was treated with a medication called trilostane for a condition related to excessive cortisol production. After just three doses, the dog developed signs of low cortisol levels, which lasted for over three months even after stopping the medication. Fortunately, the signs of high cortisol levels improved without further treatment, and after three months, the dog was started on prednisolone, which helped resolve the low cortisol symptoms. The dog needed this medication for more than a year, but it ultimately recovered well.
People also search for: Miniature Poodle low cortisol symptoms · trilostane side effects in dogs · prednisolone treatment for dogs
Abstract
A 12-year-old male neutered Miniature Poodle with confirmed pituitary-dependent hyperadrenocorticism was treated with trilostane. After three doses, it developed clinical and laboratory changes suggestive of isolated hypocortisolism ('atypical hypoadrenocorticism'), which persisted and progressed for more than 3 months despite immediate withdrawal of the trilostane. The clinical signs of hyperadrenocorticism resolved without further trilostane. After 3 months, prednisolone treatment was started and the clinical signs of hypocortisolism resolved. Prednisolone therapy was required for more than 1 year. Ultrasonography initially demonstrated large hypoechoic adrenal cortices, typical of dogs with hyperadrenocorticism, which then became small and heteroechoic, consistent with the development of adrenal necrosis. Persistent isolated hypocortisolism has not been reported previously as a complication of trilostane therapy. The case is also remarkable for the very short duration of trilostane therapy that elicited this complication. Clinicians should be aware that trilostane therapy may result in adrenal necrosis, even in the very earliest stages of therapy, but prompt action can prevent a life-threatening situation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19076773/